Neutralization of bacterial lipopolysaccharides by human plasma

Induction of human granulocyte chemiluminescence by bacterial lipopolysaccharides.

Bacterial lipopolysaccharides (LPS) have been reported to influence the oxidative response of human polymorphonuclear leukocytes (PMN). However, results sometimes conflict. In the present study, we demonstrated that activation of human PMN by LPS depends on the class (smooth [S] or rough [R]) to which the LPS belongs. Lucigenin-dependent chemiluminescence was used to assay oxygen radical produc...

Human Nod1 confers responsiveness to bacterial lipopolysaccharides.

The immune response to microbial pathogens is initiated by recognition of specific pathogen components by host cells both at the cell surface and in the cytosol. While the response triggered by pathogen products at the surface of immune cells is well characterized, that initiated in the cytosol is poorly understood. Nod1 is a member of a growing family of intracellular proteins with structural ...

bacterial lipopolysaccharides pretreatment protects

abstract   the mutagenic and immunosuppressory effects of cyclophosphamide (cyp) are still the primary limitation to wider application for treating a variety of human malignancies. on the one hand, cyp treatment predisposes transplant recipients and cancer patients to risk of bacterial, fungal, and viral infections, in the other word the, lipopolysaccharide (lps), an endotoxin found in cell wal...

Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant?

LIPID A and BACTERIAL LIPOPOLYSACCHARIDES

1. Structure and Occurrence The envelope of Gram-negative bacteria, including those of human pathogens such as Escherichia coli and Salmonella enterica, is composed of two distinct lipid membranes: an inner membrane, consisting of glycerophospholipids, and a highly distinctive outer membrane. The latter is an asymmetric bilayer, the outer leaflet of which in most species consists predominantly ...